Section outline

  • Argomenti

    2.1.  Forces at molecular and cell level 

    • Physical forces and their magnitudes at the single-molecule level
    • Modeling complex mechanical devices as protein machines by using three elements:   Spring, Dashpot, Mass
    • Mass, Stiffness and Damping of Proteins

    2.2.  Thermal forces, diffusion, and chemical forces

    •  Boltzmann’s law
    • Principle of Equipartition of Energy
    • Diffusion equation and Einstein relation
    • Autocorrelation function and Power Spectrum
    • Chemical equilibria and the effect of force on chemical equilibria
    • Rate theory of chemical reactions and the effect of force on the chemical rate constant
    • Ligand - receptor binding and unbinding, protein unfolding
    • Single molecule force spectroscopy experiments